How to cite: When referencing NSS guidelines, please cite as: Newborn Sepsis Society Clinical Practice Guidelines [Title], [Year]. Available at newbornsepsissociety.org/education/guidelines
Early-Onset Neonatal Sepsis (EOS)
Updated 2025Comprehensive recommendations for the prevention, risk assessment, diagnosis, and empiric management of EOS in term and preterm neonates. Includes the updated NSS EOS Risk Calculator and biomarker-guided decision algorithms.
Late-Onset Neonatal Sepsis (LOS)
Updated 2025Guidelines for the evaluation and management of LOS in hospitalised neonates, with a focus on CoNS bacteraemia decision-making, catheter-related infections, and duration of therapy based on organism and clinical response.
Antimicrobial Stewardship in the NICU
2024Practical framework for implementing antimicrobial stewardship in neonatal units, including empiric regimen selection, duration optimisation, IV-to-oral switch criteria, and audit tools.
Infection Prevention in the NICU
2023Evidence-based recommendations for hand hygiene, central line bundles, environmental cleaning, visitor policies, and outbreak management in neonatal intensive care settings.
Biomarkers for Neonatal Sepsis: Consensus Statement
New 2025Consensus statement on the clinical utility of CRP, PCT, IL-6, presepsin, and novel host-response biomarker panels in the diagnosis and monitoring of neonatal sepsis.