45
Participating Centres
30
Countries
15,000+
Sepsis Episodes
6
Continents
Global Sepsis Registry
The world's largest prospective registry of neonatal sepsis, capturing standardised data from NICUs across 6 continents.
About
What Is the NSS Global Sepsis Registry?
Launched in 2021, the NSS Global Sepsis Registry is a prospective, multicentre database that collects standardised information on every confirmed or suspected neonatal sepsis episode at participating sites. It is the largest and most geographically diverse registry of its kind.
The registry captures demographics, maternal risk factors, clinical presentation, laboratory results, microbiology (organism identification and antimicrobial susceptibility), treatment details, and short- and long-term outcomes. Data is entered via a secure, web-based platform with automated quality checks.
Registry Objectives
Epidemiological Surveillance
Track global trends in neonatal sepsis incidence, aetiology, and antimicrobial resistance in real time.
Quality Benchmarking
Enable participating centres to benchmark their outcomes, antibiotic use, and process measures against the network.
Research Platform
Provide a rich dataset for hypothesis-generating and hypothesis-testing research across diverse settings.
Guideline Validation
Monitor the real-world impact of NSS guideline implementation on prescribing patterns and patient outcomes.
How It Works
Step 1
Site Application
Any neonatal unit caring for infants with suspected or confirmed sepsis can apply. We welcome sites of all resource levels. The local PI must be an NSS member (institutional or individual).
Step 2
Ethics & Training
NSS provides a standardised protocol and supports local ethics/IRB applications. All data collectors complete an online training module and certification assessment.
Step 3
Data Collection
Prospective enrolment of all neonatal sepsis episodes. Data entered via the secure REDCap-based platform. Automated validation flags ensure data quality.
Step 4
Analytics & Feedback
Participating sites receive quarterly benchmarking reports comparing their metrics to the network. Aggregated data is published in the annual NSS Registry Report.
Data Governance & Access
Data protection: All data is pseudonymised at the point of entry. The registry is fully GDPR-compliant and operates under a robust data governance framework reviewed by an independent Data Safety and Monitoring Board. Contributing sites retain ownership of their data and must approve any analyses involving their centre.
Researchers wishing to access registry data for approved studies can submit a data access request through the NSS Research Committee. Priority is given to analyses that address the registry's core objectives and include investigators from contributing sites.
Our Network
Participating Regions
Registry sites span 30 countries across 6 continents, representing a diversity of healthcare settings.
14
Europe
UK, Sweden, Spain, Germany, France, Italy, Netherlands, Poland, Croatia, Greece, Portugal, Ireland, Switzerland, Czech Republic
8
Africa
Kenya, Senegal, South Africa, Nigeria, Tanzania, Uganda, Ethiopia, Ghana
5
Asia-Pacific
India, Japan, China, Australia, Saudi Arabia
3
Americas
United States, Brazil, Colombia